Quantitative proteomics for drug toxicity

Quantitative proteomics for drug toxicity.

The emerging field of toxicoproteomics has been greatly advanced by quantitative proteomic technologies and their increasing applications in toxicology. The discipline is focused on the proteomic study of toxicity caused by toxic substances, including but not limited to drugs, toxins, environmental stressors, chemicals and any other materials that induce significant pathological responses. Drug...

Software platforms for quantitative proteomics

In recent years, it has become obvious that mRNA expression does not always correlate with protein expression. It seems that a full understanding of the complexity of life can only be obtained by examining abundances of proteins under varying conditions. Accurate measurements of these expression values is crucial. This field of research also requires new computational efforts since the data, of...

Magnetoresistive Biosensors for Quantitative Proteomics

Protein detection and quantification is routinely performed in laboratories around the world for in-vitro diagnostics. Many different sensing platforms, such as mass spectrometry, optical biosensors, electrochemical biosensors, magnetic biosensors, etc., have been developed for quantitatively detection. The sandwich immunoassay is widely used as a labeled detection method due to its high specif...

Application of Proteomics Technologies in the Drug Development Process

Quantitative Proteomics of Lymphocytes

Lymphocytes are the best-studied higher eukaryote cells. In this report, quantitative relationships of the protein components in resting cell, blast cell and plasma cell types are evaluated. The comparison of these cell types leads to the conclusion that resting cells synthesize about one-twentieth of the protein species as compared to blast cells. Blast cells seem to be metabolically the most ...